Overweight, diabetes, NASH
In our meal and diet response models we currently are working on disease progression of NAFLD and accumulation of insulin resistance. In the description of diet responses we do not only model the buildup of hepatic fat, but also fat on a whole body level and the change of lean body mass. The mechanistic description of both fat and lean mass changes, and progression of insulin resistance provides a foundation is a great example of what we as a research group are working towards: A mechanistic whole-body model which may be used for metabolic insights of the impact our everyday life may have on our health.